tissue damage detection by osmotic surveillance
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tissue damage detection by osmotic surveillance
The Cell Nucleus Serves as a …- tissue damage detection by osmotic surveillance ,Tissue damage activates cytosolic phospholipase A 2 (cPLA 2), releasing arachidonic acid (AA), which is oxidized to proinflammatory eicosanoids by 5-lipoxygenase (5-LOX) on the nuclear envelope.How tissue damage is sensed …Tissue Damage Signaling Is a Prerequisite for Protective ...2018-5-15 · Absence of Osmotic Tissue Damage Signaling Does Not Block Microbial Detection (A) Left panel, Venn plot of significantly (p adj <0.05), at least two times up- or downregulated mRNAs at 60 min after ear infection in the absence (Iso + PA) or presence (Hypo + PA) of osmotic tissue damage signaling. Right panel, log2-fold regulation of ...
Synapse - Tissue damage detection by osmotic surveillance
Tissue damage detection by osmotic surveillance: Abstract: How tissue damage is detected to induce inflammatory responses is unclear. Most studies have focused on damage signals released by cell breakage and necrosis. Whether tissues use other cues in addition to cell lysis to detect that they are damaged is unknown.
Philipp Niethammer | Semantic Scholar
2004-3-19 · Osmotic surveillance mediates rapid wound closure through nucleotide release ... Tissue damage detection by osmotic surveillance. B. Enyedi, S. Kala, Tijana Nikolich ... differences between interstitial fluid and the external environment mediate rapid leukocyte recruitment to sites of tissue damage in zebrafish by activating cytosolic ...
Tissue damage detection by osmotic surveillance | Article ...
Article “Tissue damage detection by osmotic surveillance” Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, and Sparking, linking science and technology information which hitherto stood alone to support the generation ...
Dr. Tijana Tuhy, MD | Baltimore, MD | Pulmonologist | US ...
Tissue damage detection by osmotic surveillance Balázs Enyedi, Snigdha Kala, Tijana Nikolich-Zugich, Philipp Niethammer Disease modification of breast cancer-induced bone remodeling by ...
Tissue damage detection by osmotic surveillance | …
How tissue damage is detected to induce inflammatory responses is unclear. Most studies have focused on damage signals released by cell breakage and necrosis. Whether tissues use other cues in addition to cell lysis to detect that they are damaged is unknown. We find that osmolarity differences between interstitial fluid and the external environment mediate rapid leukocyte …
(PDF) Tissue damage detection by osmotic surveillance
2013-8-11 · T issue damage detection by osmotic surveillance Balázs Enyedi , Snigdha Kala , Tijana Nikolich-Zugich and Philipp Niethammer 1,2 How tissue damage is detected to induce inflammatory responses is...
Tissue damage detection by osmotic surveillance
2013-10-11 · Enyedi B, Kala S, Nikolich-Zugich T, Niethammer P. Tissue damage detection by osmotic surveillance. Nat Cell Biol. 2013 Sep;15(9):1123-30. doi: 10.1038/ncb2818
Osmotic surveillance mediates rapid wound closure …
detection and repair are obligatory tissue-intrinsic processes, or ... transparency of zebrafish tail fins facilitates interrogation of tissue damage detection mechanisms through pharmacologic/genetic ... the inside of the tissue. Osmotic surveillance mediates rapid wound closure through nucleotide release
Osmotic surveillance mediates rapid wound closure …
Osmotic cues from the environment mediate rapid detection of epithelial breaches by leukocytes in larval zebrafish tail fins. Using intravital luminescence and fluorescence microscopy, we now show that osmolarity differences between the interstitial fluid and the external environment trigger ATP release at tail fin wounds to initiate rapid wound closure through long-range activation of …
Tissue damage detection by osmotic surveillance
Thus, tissues can detect damage through direct surveillance of barrier integrity, with cell swelling probably functioning as a pro-inflammatory intermediate in the process. Publication types Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't MeSH terms Animals Arachidonic Acids / immunology Arachidonic Acids / metabolism
Synapse - Tissue damage detection by osmotic surveillance
Tissue damage detection by osmotic surveillance: Abstract: How tissue damage is detected to induce inflammatory responses is unclear. Most studies have focused on damage signals released by cell breakage and necrosis. Whether tissues use other cues in addition to cell lysis to detect that they are damaged is unknown.
The Early Wound Signals - ncbim.nih.gov
Enyedi B, Kala S, Nikolich-Zugich T, Niethammer P. Tissue damage detection by osmotic surveillance. [Internet] Nat Cell Biol. 2013; 15:1123–30. This study identified a role for cell swelling and eicosanoids in the rapid detection of skin wounds by leukocytes using intravital imaging in zebrafish. [PMC free article] [Google Scholar]
Quantitative Imaging of Endogenous and Exogenous …
2019-6-7 · Enyedi B, Kala S, Nikolich-Zugich T, Niethammer P (2013) Tissue damage detection by osmotic surveillance. Nat Cell Biol 15(9):1123–1130 CrossRef Google Scholar 18.
Supplemental Materials for Hypo-osmotic Stress Drives IL ...
2018-8-15 · Figure 5 Hypo-osmotic stress is a relevant tissue signal. (a–d) Normal human skin tissue was either (a) immediately fixed in formalin or cultured ex vivo for 24 hours in (b) normal medium, (c) hypo-osmotic medium, or (d) with addition of IFN-γ with subsequent formalin fixation. Dotted line marks dermoepidermal junction.
Osmotic surveillance mediates rapid wound closure …
2022-3-14 · Osmotic cues from the environment mediate rapid detection of epithelial breaches by leukocytes in larval zebrafish tail fins. Using intravital luminescence and fluorescence microscopy, we now show that osmolarity differences between the interstitial fluid ...
SIAT® Tissue Damage Studies - Creative Biolabs
Frequently Asked Questions (FAQs) Knowledge Center; Support Documents; Newsletter; Resources With deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all …
Lipid peroxidation regulates long-range wound …
2020-8-31 · Huang, C. & Niethammer, P. Tissue damage signaling is a prerequisite for protective neutrophil recruitment to microbial infection in zebrafish. Immunity 48 , 1006–1013.e6 (2018). CAS Article ...
Osmotic surveillance mediates rapid wound closure …
Osmotic cues from the environment mediate rapid detection of epithelial breaches by leukocytes in larval zebrafish tail fins. Using intravital luminescence and fluorescence microscopy, we now show that osmolarity differences between the interstitial fluid and the external environment trigger ATP release at tail fin wounds to initiate rapid wound closure through long-range activation of …
Journal Club: Wound Healing/Ions | Synapse
2013-10-10 · Presentation: “Adding In-salt to Injury: Tissue Damage Detection by Osmotic Surveillance” Presenter: Carlos Rojo <(second-year BMS student) Paper: Enyedi B., et al. “Tissue damage detection by osmotic surveillance.”Nat Cell Biol. <2013 Sep;15(9):1123-30. In a nutshell: Generally, even we non-physicians know how to dress a small wound. Wash the area with …
tissue damage detection by osmotic surveillance data
Factory Environment. Cooperative Partner. Hypo-osmotic Stress Drives IL-33 Production in Human ...- tissue damage detection by osmotic surveillance data ,Jan 01, 2019·Moreover, osmotic surveillance mediated effective wound closure by epithelial cells in the same model through an adenosine triphosphate-dependent mechanism (Gault et al., 2014).Together, these …
Philipp Niethammer: Publications | Sloan Kettering Institute
2022-3-1 · Gault WJ, Enyedi B, Niethammer P. Osmotic surveillance mediates rapid wound closure through nucleotide release. J Cell Biol. 2014 Dec 22;207(6):767–782. PMCID: PMC4274268. Niethammer P. Stress heals. Dev Cell. 2014 Oct 13;31(1):5–6. PMID: 25313958. Enyedi B, Kala S, Nikolich-Zugich T, Niethammer P. Tissue damage detection by osmotic ...
Cureus | Tissue damage detection by osmotic surveillance
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Philipp Niethammer: Publications - Sloan Kettering Institute
2022-3-18 · Enyedi B, Kala S, Nikolich-Zugich T, Niethammer P. Tissue damage detection by osmotic surveillance. Nat Cell Biol. 2013 Sep;15(9):1123–1130. PMCID: PMC3826879
Tissue damage detection by osmotic surveillance | Article ...
Article “Tissue damage detection by osmotic surveillance” Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, and Sparking, linking science and technology information which hitherto stood alone to support the generation ...